The Hippocampus and Mental Health

Previous studies have shown that when people are healthy, those with less grey matter in the hippocampus have a higher risk of developing disorders like Alzheimer's Disease, post-traumatic stress disorder (PTSD), Schizophrenia, and depression. In other words, a small hippocampus predisposes people to be at a greater risk of being later diagnosed with a mental illness. For example when older adults complained about having memory difficulties, those with a small hippocampus were the ones who were diagnosed with Alzheimer's disease 5 years later. People with a larger hippocampus were protected against Alzheimer's disease. For this reason, it is important to have a larger hippocampus when still healthy, in order to reduce the risk of getting diagnosed with a mental disorder.


Scientific studies suggest that people who have a larger hippocampus are less likely to later develop Alzheimer's disease, but also PTSD, depression, and Schizophrenia. Other disorders are also associated with a small hippocampus, namely traumatic brain injury, ADHD, addiction, obsessive compulsive disorders, bipolar disorders, Parkinson's etc. A larger hippocampus is associated with healthy cognition. So generally speaking a healthy hippocampus is associated with better mental health.


The Hippocampus and Episodic Memory

What is memory? Memories are the brain’s special way of encoding, storing and recalling information which comes into the brain. This information is categorized and stored for later retrieval. 

There are different types of memory:
1). Semantic Memory: remembering factual information. An example is the knowledge that the Eiffel Tower is in Paris. 
2). Episodic Memory: our memory of events that occurred in a specific time and place. For example, what you did on New Year's Eve.

An important part of episodic memory is spatial memory: the "place" information relating to a specific event we are trying to remember. The first thing we often remember is where an event actually took place, so this ability to learn and recall the spatial layout of an environment is very important. It can also be used in the present by helping us orient ourselves in environments, navigate them, and locate objects within them.

Only Episodic Memory relies on the critical contribution of the hippocampus. Patients with selective damage to the hippocampus can learn semantic facts normally. For this reason, not all memory training programs will stimulate the hippocampus.

Eiffel Tower
New Year's Eve

The Hippocampus and Spatial Memory

As with episodic memory, spatial memory critically relies on the hippocampus. Specifically, the hippocampus allows us to build cognitive maps of environments that we need to navigate. Cognitive maps are mental representations of an environment formed by the learning of spatial relationships between environmental landmarks (reference points, such as trees, rivers, mountains or buildings). Cognitive maps are continuously forming and updating as we navigate. 


Our Hippocampus allows us to navigate environments effectively using cognitive maps — it's like a built-in GPS!

Hippocampus Over Time


As we get older, the size (volume) of our hippocampus decreases. A smaller hippocampus is a serious risk factor for developing neurological conditions like dementia and Alzheimer's Disease. 

The more we use our hippocampus across our lifetime, the more we can fight back this decline and counteract the risk of developing conditions like dementia. 


The Caudate Nucleus of the Striatum

Using cognitive maps and the hippocampus isn't the only way we can navigate. There is a different system, which recruits a part of the brain called the caudate nucleus of the striatum. After traveling the same route in an environment over time, navigating can become a habit or a routine. We don't need to think about the path we take anymore, it's more automatic, like being on an auto-pilot. This type of navigation is called stimulus-response because it evolves out of making the same response at a given situation multiple times (for example, always turning left at the end of the street to go to the store).


A large Caudate Nucleus has been shown to be associated with Alzheimer's Disease. 


Navigation Strategies

Spatial strategy

The SPATIAL STRATEGY, which relies on the hippocampus, involves building relationships between environmental landmarks, such as buildings or parks, to form cognitive maps (mental maps) of an area. 

Response Strategy

The RESPONSE STRATEGY relies on the caudate nucleus of the striatum. It involves learning a route by performing a sequence of movements (e.g., turn right) from specific points (e.g., at the hospital). The RESPONSE STRATEGY does not involve building a cognitive map.


Competing systems

The hippocampal-mediated navigation system and the caudate nucleus-dependent system compete. Although we can use both, we cannot use them at the same time.

Competing Strategies

Our research shows that the larger our caudate nucleus becomes, the smaller our hippocampus gets. These two brain regions compete.


WE USE Spatial Strategies less as we age

Research shows that we use spatial strategies less as we get older, in favour of more automatic, stimulus-response driven navigation. That means we are naturally less reliant on hippocampus dependent cognitive maps as we age. 

This could be related to the natural decline in the size of the hippocampus, contributing to more response strategy use. There are other factors to consider as well, such as an increasing reliance on technology, stress and reward which promote stimulus-response strategies. 

Strategies over time

The risk associated with over-use of response strategies:

  1. Your RESPONSE STRATEGY mode is very strong and is constantly active, especially when you are in a hurry and do not have time to build cognitive maps, when you perform routine actions, and when you feel stressed and fall back to autopilot.

  2. The RESPONSE STRATEGY can dominate over the SPATIAL STRATEGY and this can lead to reduced stimulation of the hippocampus.

However, RESPONSE STRATEGIES can be efficient to help you create healthy habits.

As always, balance is the key!


How Vebolife helps

Vebolife is a software specially designed to strengthen the hippocampus, helping you maintain that all-important balance. The program is composed of 46 virtual environments, which increase in difficulty as you progress through the training. A focus is placed on novelty to encourage the formation of new relationships, which recruits the hippocampus. All the tasks were specially designed to maximize the use of spatial memory requiring the hippocampus, by forming relationships between objects and yourself, and by using cognitive maps. 

Vebolife is different than other brain training programs because it is the only cognitive training software proven to stimulate the hippocampus. It's challenging and elements of reward that are built into other program are not present in Vebolife. This is because our reward system is closely tied to the caudate nucleus and we need to avoid this if we are to focus on our hippocampus. Further, the Vebolife software adjusts the level of difficulty so that it allows us to make errors, since learning through errors stimulates the Hippocampus.


If you're serious about improving your mental health by stimulating the hippocampus then Vebolife is the right tool for you!